Welcome to the John Burke Lab at the University of Victoria. We are interested in studying the molecular basis for how enzymes that modify lipid phosphoinositides and the Ras superfamily of G proteins are regulated. These enzymes mediate many important cellular functions including growth, membrane trafficking, cytokinesis, and proliferation. Due to the key roles that these enzymes play they are frequently involved in many human diseases. The main goal of our research is to define the mechanism of how theses enzymes are involved in disease, and design novel therapeutic strategies for treating disease.
We address this problem using an innovative mixture of biophysical tools, primarily focusing on structural mass spectrometry and X-ray crystallography. More details on the research methodology are provided in the research section.
We are currently recruiting new undergraduate and graduate students. Please send Dr Burke an updated CV and brief paragraph on why you are interested in our research.
Burke Lab, 270 Petch Building, Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada